Cagrilintide (C₁₉₄H₃₁₂N₅₄O₅₉S₂, 37aa synthetic research peptide, MW ~4,409 Da, CAS 1415456-99-3). Acylated amylin-backbone peptide with N14E, V17R, P37Y substitutions and a C20 fatty diacid, for in vitro amylin receptor (AMY1/AMY2/AMY3) binding characterization and cAMP signaling assay research. ≥99% purity, lyophilized.
Cagrilintide
Sale price: $46.74
- Lab-grade COA
- 99%+ purity
- Most orders ship within 24 hours.
- Refund-backed
- All Precisely Peptides research peptides are USA-sourced and synthesized in the USA.Black Label research peptides are produced in cGMP facilities.
Description
Cagrilintide is a synthetic 37-amino acid research peptide (CAS 1415456-99-3, molecular formula C₁₉₄H₃₁₂N₅₄O₅₉S₂, MW ~4,409 Da) constructed on a native human amylin (islet amyloid polypeptide, IAPP) backbone. The peptide retains the Cys2–Cys7 disulfide bridge of native amylin and incorporates three residue substitutions — N14E, V17R, and P37Y — along with an N-terminal C20 eicosanedioic fatty diacid conjugated via a γ-glutamic acid spacer enabling in vitro albumin-binding behavior.
In laboratory research, Cagrilintide is utilized in amylin receptor complex binding studies across AMY1 (CTR + RAMP1), AMY2 (CTR + RAMP2), and AMY3 (CTR + RAMP3), calcitonin receptor (CTR) binding characterization, Gs-coupled cAMP accumulation assays (reported EC50 ~49 pM at hAMY3R, ~62 pM at hCTR), receptor-binding affinity determinations (Ki ~3.5 nM at hAMY3R, ~6.8 nM at hCTR), and comparative in vitro structure–activity studies against other amylin-backbone research peptides.
Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.
Third-Party Lab Analysis
Available certificates are independently tested by a USA-based, ISO/IEC 17025-accredited third-party laboratory. Download or preview each documented lot below.
5mg
Additional information
| Vial Size | 5mg |
|---|
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