PP-3R (Retatrutide)

Description

PP-3R is a synthetic 39-amino acid research peptide (CAS 2381089-83-2, molecular formula C₂₂₁H₃₄₂N₄₆O₆₈) constructed on a GIP (glucose-dependent insulinotropic polypeptide) backbone with in vitro binding activity characterized at the glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). The peptide incorporates three non-coded amino acid residues: α-aminoisobutyric acid (Aib) at positions 2 and 20 for resistance to dipeptidyl peptidase-IV (DPP-IV) enzymatic degradation, and α-methyl-L-leucine (αMeL) at position 13 for optimized in vitro binding at GIPR and GCGR. A C20 fatty diacid moiety is conjugated via a linker at Lys17 to enable non-covalent in vitro albumin binding.

In laboratory research, PP-3R is used in multi-receptor binding-affinity studies, GLP-1R/GIPR/GCGR cellular signaling crosstalk investigations, cAMP accumulation assays across receptor-expressing cell lines, cellular energy-metabolism modulation experiments in cell-culture models, metabolic signaling pathway studies, and comparative in vitro structure–activity studies against multi-receptor and mono-receptor research-grade reference peptides. Cryo-EM structural studies have characterized distinct binding poses of PP-3R at each target receptor, revealing receptor-specific ECL1 recognition mechanisms.

Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.