PP-2T (Tirzepatide)

Description

PP-2T is a synthetic 39-amino acid research peptide (CAS 2023788-19-2, molecular formula C₂₂₅H₃₄₈N₄₈O₆₈, MW ~4,813.45 Da) constructed on a native GIP (glucose-dependent insulinotropic polypeptide) backbone. The peptide features two non-natural α-aminoisobutyric acid (Aib) residues at positions 2 and 13 for dipeptidyl peptidase-IV (DPP-IV) resistance, and a C20 fatty diacid (eicosanedioic acid) conjugated to Lys20 via a glutamic acid and dual AEEA (aminoethoxyethoxyacetic acid) linker enabling in vitro albumin-binding behavior. In cellular assays, PP-2T exhibits imbalanced binding affinity favoring GIPR over GLP-1R and demonstrates biased signaling toward cAMP generation over β-arrestin recruitment at GLP-1R.

In laboratory research, PP-2T is utilized in dual-receptor cAMP accumulation assays, biased-signaling characterization at GLP-1R, GIPR-mediated cAMP pathway activation studies, branched-chain amino acid (BCAA) catabolism investigations in brown adipose tissue cell models, comparative in-vitro structure–activity studies versus single-receptor (GLP-1R-only) research peptides, and Akt/mTOR signaling pathway research.

Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.