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Semax (C₃₇H₅₁N₉O₁₀S, 7aa synthetic peptide on the ACTH(4-10) sequence, MW ~814 Da, CAS 80714-61-0). MC4R/MC5R ligand and enkephalinase inhibitor for neurotrophic signaling research. ≥99% purity, lyophilized.

Specifications
Formula C₃₇H₅₁N₉O₁₀S
CAS 80714-61-0
Neuropeptide Receptor & CNS Signaling

Semax

For Research Use Only — Not for Human Consumption

Sale price: $36.85

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Certificate of Analysis preview
Certificate of Analysis
Lot 05/13/2026 · purity confirmed by HPLC
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  • Lab-grade COA
  • 99%+ purity
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  • Refund-backed
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Description

Semax is a synthetic heptapeptide on the ACTH(4-10) sequence with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, molecular formula C₃₇H₅₁N₉O₁₀S, a molecular weight of approximately 813.97 Da, and CAS number 80714-61-0. The C-terminal Pro-Gly-Pro extension enhances peptidase resistance (aminopeptidase and carboxypeptidase) and in-vitro stability.

In laboratory research, Semax is utilized in melanocortin receptor (MC4R, MC5R) interaction studies (where it shows partial-binding/displacement behavior in research models), BDNF expression-regulation experiments (1.4-fold increase, 1.6-fold TrkB phosphorylation in hippocampal models), nerve growth factor (NGF) pathway investigations, enkephalinase inhibition assays (IC₅₀ ~10 μM), dopaminergic and serotonergic neurotransmission studies, hippocampal LTP (long-term potentiation) electrophysiology, and CREB phosphorylation signaling research.

Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.

Third-Party Lab Analysis

Available certificates are independently tested by a USA-based, ISO/IEC 17025-accredited third-party laboratory. Download or preview each documented lot below.

10mg

Lot: PP412-26-001Tested: 05/13/2026
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Additional information

Vial Size

10mg

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