MT-1 (Melanotan-1/Afamelanotide, C₇₈H₁₁₁N₂₁O₁₉, 13aa, MW ~1,647 Da, CAS 75921-69-6). Synthetic peptide that binds selectively at MC1R for in-vitro melanocyte receptor-binding studies, tyrosinase/MITF, eumelanin-synthesis, and melanocortin-signaling research. ≥99% purity, lyophilized. Research use only. Not for human consumption.
Melanotan I
Synthetic peptide that binds selectively at MC1R for in-vitro melanocyte receptor-binding studies, tyrosinase/MITF, eumelanin-synthesis,…
$36.34
$30.89
| Title | Range | Discount |
|---|---|---|
| Bulk Discount | 3 - 5 | 5% |
| Bulk Discount | 6 - 10 | 10% |
| >11 Bulk Discount | 11 + | 15% |
Buy more, save more: 5% off at 3+ · 10% off at 6+ · 15% off at 11+. Applied automatically at checkout.
- Lab-grade COA
- 99%+ purity
- 24-hour shipping
- Refund-backed
For research use only. Not for human consumption. All products are sold strictly as reference standards for in-vitro laboratory research and are not intended to diagnose, treat, cure, or prevent any disease.
Description
MT-1 (Melanotan-1, Afamelanotide) is a synthetic 13-amino acid linear peptide on the alpha-melanocyte-stimulating-hormone (α-MSH) backbone, with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂, molecular formula C₇₈H₁₁₁N₂₁O₁₉, a molecular weight of approximately 1,646.85 Da, and CAS number 75921-69-6. MT-1 features a norleucine (Nle) substitution at position 4 and a D-phenylalanine (D-Phe) at position 7, conferring enhanced in-vitro stability and approximately 100-fold increased MC1R binding affinity compared to the native α-MSH sequence in published research models. MT-1 binds selectively at the melanocortin-1 receptor (MC1R) with minimal binding at MC3-5R subtypes.
In laboratory research, MT-1 is utilized in MC1R signaling studies, melanocyte receptor binding pathway investigations (tyrosinase, TRP-1, TRP-2 activation), MITF transcription factor regulation, cAMP/CREB phosphorylation assays, eumelanin/pheomelanin synthesis ratio determinations, and UV-induced DNA damage response studies in melanocyte cell models.
Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.
Third-Party Lab Analysis
Every batch is independently tested by a USA-based, ISO/IEC 17025-accredited third-party laboratory. Download or preview the Certificate of Analysis for each lot below.
10mg
Additional information
| Vial Size | 10mg |
|---|
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