SS-31

Description

SS-31, also known as elamipretide (synonyms MTP-131, Bendavia; sequence H-D-Arg-Dmt-Lys-Phe-NH₂, where Dmt = 2′,6′-dimethyl-L-tyrosine), is a synthetic aromatic-cationic Szeto-Schiller mitochondria-targeting tetrapeptide. Molecular formula C₃₂H₄₉N₉O₅ (free base), molecular weight ~639.79 Da, CAS 736992-21-5 (free base; acetate salt 1334953-95-5). It is a non-proteinogenic peptide containing a D-arginine residue and an unnatural dimethyltyrosine residue with a C-terminal primary amide, studied for its potential-independent partitioning into the inner mitochondrial membrane and association with the phospholipid cardiolipin.

In laboratory research, SS-31 is utilized in in-vitro studies of mitochondrial bioenergetics (e.g., oxygen-consumption-rate / Seahorse-style respiration assays), electron-transport-chain coupling and respiratory-supercomplex assembly investigations (e.g., BN-PAGE), cardiolipin-binding and lipid-interaction biophysical assays, reactive-oxygen-species and oxidative-stress assay development in cultured cells (e.g., MitoSOX-type readouts), mitochondrial-membrane-potential and cristae-ultrastructure morphology studies (e.g., TMRM/JC-1, electron/fluorescence microscopy), and as a reference standard for HPLC and LC-MS analytical method development.

Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.

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