MT-1 (Melanotan-1/Afamelanotide, C₇₈H₁₁₁N₂₁O₁₉, 13aa, MW ~1,647 Da, CAS 75921-69-6). Synthetic peptide that binds selectively at MC1R for in-vitro melanocyte receptor-binding studies, tyrosinase/MITF, eumelanin-synthesis, and melanocortin-signaling research. ≥99% purity, lyophilized.
Melanotan I
$37.16
- Lab-grade COA
- 99%+ purity
- Most orders ship within 24 hours. Orders placed Saturday or Sunday ship Monday.
- Refund-backed
- All Precisely Peptides research peptides are USA-sourced and synthesized in the USA.Black Label research peptides are produced in cGMP facilities.
Description
MT-1 (Melanotan-1, Afamelanotide) is a synthetic 13-amino acid linear peptide on the alpha-melanocyte-stimulating-hormone (α-MSH) backbone, with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂, molecular formula C₇₈H₁₁₁N₂₁O₁₉, a molecular weight of approximately 1,646.85 Da, and CAS number 75921-69-6. MT-1 features a norleucine (Nle) substitution at position 4 and a D-phenylalanine (D-Phe) at position 7, conferring enhanced in-vitro stability and approximately 100-fold increased MC1R binding affinity compared to the native α-MSH sequence in published research models. MT-1 binds selectively at the melanocortin-1 receptor (MC1R) with minimal binding at MC3-5R subtypes.
In laboratory research, MT-1 is utilized in MC1R signaling studies, melanocyte receptor binding pathway investigations (tyrosinase, TRP-1, TRP-2 activation), MITF transcription factor regulation, cAMP/CREB phosphorylation assays, eumelanin/pheomelanin synthesis ratio determinations, and UV-induced DNA damage response studies in melanocyte cell models.
Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.
Additional information
| Vial Size | 10mg |
|---|
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