5-Amino-1MQ

Description

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule quinolinium compound with the molecular formula C₁₀H₁₁N₂⁺ (supplied as the iodide salt, C₁₀H₁₁IN₂, MW ~286.11 Da) and CAS number 42464-96-0. 5-Amino-1MQ is a substrate-site-targeting, selective inhibitor of nicotinamide N-methyltransferase (NNMT) with an IC₅₀ of 1.2 μM (at 50 μM SAM, 100 μM nicotinamide). NNMT catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). By inhibiting NNMT, 5-Amino-1MQ modulates the cellular SAM/SAH methyl donor ratio and sirtuin-1 (SIRT1) activity.

In laboratory research, this compound is utilized in 3T3-L1 adipocyte differentiation assays (EC₅₀ ~30 μM for lipid accumulation reduction), 1-MNA level measurements in cell culture models (EC₅₀ ~2.3 μM), myoblast differentiation and muscle stem cell fusion studies, metabolic flux analysis, and epigenetic methylation dynamics investigations. Notably, 5-Amino-1MQ demonstrates selectivity for NNMT without affecting related methyltransferases or other enzymes in the methyltransferase family.

Supplied as a high-purity powder (≥99% by HPLC). For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.