5-Amino-1MQ (C₁₀H₁₁N₂⁺ cation, iodide salt C₁₀H₁₁IN₂, CAS 42464-96-0). Selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀ 1.2 µM) for laboratory research involving metabolic pathways and cellular signaling. ≥99% purity, lyophilized.
5-Amino-1MQ
$64.80
- Lab-grade COA
- 99%+ purity
- Most orders ship within 24 hours. Orders placed Saturday or Sunday ship Monday.
- Refund-backed
- All Precisely Peptides research peptides are USA-sourced and synthesized in the USA.Black Label research peptides are produced in cGMP facilities.
Description
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule quinolinium compound with the molecular formula C₁₀H₁₁N₂⁺ (supplied as the iodide salt, C₁₀H₁₁IN₂, MW ~286.11 Da) and CAS number 42464-96-0. 5-Amino-1MQ is a substrate-site-targeting, selective inhibitor of nicotinamide N-methyltransferase (NNMT) with an IC₅₀ of 1.2 μM (at 50 μM SAM, 100 μM nicotinamide). NNMT catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). By inhibiting NNMT, 5-Amino-1MQ modulates the cellular SAM/SAH methyl donor ratio and sirtuin-1 (SIRT1) activity.
In laboratory research, this compound is utilized in 3T3-L1 adipocyte differentiation assays (EC₅₀ ~30 μM for lipid accumulation reduction), 1-MNA level measurements in cell culture models (EC₅₀ ~2.3 μM), myoblast differentiation and muscle stem cell fusion studies, metabolic flux analysis, and epigenetic methylation dynamics investigations. Notably, 5-Amino-1MQ demonstrates selectivity for NNMT without affecting related methyltransferases or other enzymes in the methyltransferase family.
Supplied as a high-purity powder (≥99% by HPLC). For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.
Additional information
| Vial Size | 50mg |
|---|
Related products
-
This product has multiple variants. The options may be chosen on the product page
BPC-157
Price range: $20.89 through $38.34 -
Select options This product has multiple variants. The options may be chosen on the product page
KissPeptin
$42.88 -
Select options This product has multiple variants. The options may be chosen on the product page
Ipamorelin
Price range: $45.99 through $57.29 -
Select options This product has multiple variants. The options may be chosen on the product page
GLOW
$85.12
