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TB-500 (C₂₁₂H₃₅₀N₅₆O₇₈S, 43aa thymosin β4 fragment, MW ~4,964 Da, CAS 77591-33-4). LKKTETQ actin-binding peptide for cell migration, cytoskeletal dynamics, MMP regulation, and endothelial tube formation research. ≥99% purity, lyophilized.

Specifications
Formula C₂₁₂H₃₅₀N₅₆O₇₈S
Mol. Wt. 4,963.50 Da
CAS 77591-33-4
Cell Migration & Cytoskeletal Signaling

TB-500

For Research Use Only — Not for Human Consumption

Sale price: $42.07

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Certificate of Analysis preview
Certificate of Analysis
Lot 06/29/2026 · purity confirmed by HPLC
View COA (PDF)
  • Lab-grade COA
  • 99%+ purity
  • Most orders ship within 24 hours.
  • Refund-backed
  • All Precisely Peptides research peptides are USA-sourced and synthesized in the USA.

Description

TB-500 is a synthetic 43-amino acid peptide (molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S, MW ~4,963.50 Da, CAS 77591-33-4) representing the biologically active region of thymosin beta-4 (Tβ4), the principal G-actin sequestering molecule in eukaryotic cells. The active domain centers on the actin-binding motif LKKTETQ (residues 17-23) responsible for G-actin binding and polymerization regulation.

In laboratory research, TB-500 is utilized in actin cytoskeleton dynamics studies, scratch wound closure assays and transwell migration assays, lamellipodium formation investigations, MMP expression modulation studies, endothelial cell tube formation assays (Matrigel), keratinocyte migration experiments, stem cell differentiation models, Wnt signaling pathway interaction studies, hair follicle stem cell activation research, and cardiac progenitor cell biology investigations.

Supplied as a lyophilized powder with ≥99% purity verified by HPLC. For storage and handling conditions, refer to the Certificate of Analysis provided with each lot. This product is intended strictly for laboratory research use only (RUO) and is not for human consumption, therapeutic use, or any diagnostic purposes.

Third-Party Lab Analysis

Available certificates are independently tested by a USA-based, ISO/IEC 17025-accredited third-party laboratory. Download or preview each documented lot below.

10mg

Lot: PP618-26-001Tested: 06/29/2026
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Additional information

Vial Size

10mg

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